The collection has been maintained in its original order; alphabetically within a chronological framework. The overall arrangement has been divided into three main series: Correspondence, Subject Files, and Alumni Catalogue (1927). There are also miscellaneous materials, oversize, scrapbooks, and photographs.

The Correspondence series consists of personal and professional correspondence between Frank S. Kedzie and colleagues, circa 1901-1933. Significant among the early papers are documents concerning the settlement of his father's estate. Professionally related correspondence includes exchange with: John Beaumont on the establishment and dedication of Beaumont Tower in 1929; with Charles W. Garfield, member of the State Board of Agriculture (1887-1899), on the establishment of a bronze memorial tablet commemorating Dr. Manly Miles, first Professor of Practical Agriculture; with Henry A. Haigh, class of 1878, on Kedzie's involvement in the establishment of the sugar-beet industry in Michigan; and with President Robert Shaw regarding Kedzie's dismissal in 1932. The correspondence from John Beaumont from 1928 includes a list of the items placed in the cornerstone of Beaumont Tower.

The Subject Files series covers a broad array of topics. There are documents concerning matters of college administration such as: handwritten minutes of faculty meetings; party request slips by various organizations for permission to use campus buildings; student medical excuses from class attendance; and papers relating to college expenditures. There are also materials pertaining to Kedzie's career as college historian, that include: essays written by Kedzie on the history of M.A.C.; rosters of students and faculty involved in the military service; and information on the first Patriarch’s Dinner (1929), which Kedzie initiated. Also found in this series are papers regarding Kedzie's personal life, including: information on Kedzie's dogs and horses; two photograph albums of the Kedzie-Marvin family, and; two volumes of the Marvin family bible, one of which includes a family record.

The Alumni Catalogue series (1927) consists of letters from Kedzie to alumni of M.A.C.(now Michigan State University) requesting personal information for inclusion in an updated Alumni Catalogue.