The Kedzie family papers consists of genealogies, correspondence, and books published by members of the family. Also included are photographs of Robert Mark Kedzie, Ester Hawley Kedzie, A. S. Kedzie, and unidentified men. Additionally, there are items relating to Michigan Agricultural College/Michigan State College (now Michigan State University), such as a 1907 Alumni luncheon program, a commencement program, and a brochure which seeks donations for various buildings titled "For the Veterans of World War II."

Also included in the collection are letters to and from Robert Clark Kedzie, dating from 1860 to 1898. Many of these letters date from his time serving as a surgeon in the Civil War.