The early records document the major projects taken on by the Institute of Biology and Medicine in fulfilling its objectives. Those were the establishment of the College of Human Medicine, the construction of the Life Science Building I, the construction of the Encapsulated Health Care Facility (a project which failed after considerable effort), the construction of the Clinical Sciences building, and the establishment of the College of Osteopathic Medicine. The material is best described as project files with supporting research files. It is not, strictly speaking, documentation of the day to day functioning of the Institute, but it is detailed documentation of the individual projects. Consequently, series are established by project and arranged alphabetically. The reference files for research on two-year medical programs in the United States, which consist of materials collected on visits to institutions with such programs, are grouped as one series due to their bulk and indirect relationship to the establishment of such a program at Michigan State University.

Blueprints and copies from various construction and renovation projects related to health education have been separated into a series and have restricted access.

Subsequent records are arranged by subject and include many of the day to day functions of the MSU HealthTeam.